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Inhibition of the cardiac ATP-dependent potassium current by KB-R7943
Front Pharmacol
2017 Sep 18
6S)-4-amino-6-methyl-5-[(2R)-oxan-2-yloxy]oxan-2-yl]oxy}-6
AZD1208 - CAS# 1204144-28-4 Size:Solid 2 mg Inhibition of the cardiac ATP-dependentAZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine threonine kinases, which may result in the interruption of the G1 S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is